Quantitative determination of trinitroglycerin in human plasma.
نویسندگان
چکیده
منابع مشابه
Quantitative determination of trinitroglycerin in human plasma.
We developed a simplified method for quantitative measurement of trinitroglycerin in human plasma using hexane extraction and analysis by gas-liquid chromatography with electron-capture detection. This assay was linear from 0.5-60 ng/ml. Sensitivity and reproducibility were +/- 0.5 ng/ml. We used this assay to evaluate the pharmacodynamics of trinitroglycerin in 14 patients. Maximum plasma leve...
متن کاملQuantitative Determination of Pentoxifylline in Human Plasma
A rapid, optimized, and sensitive reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for determination of pentoxifylline in human plasma. The analyte was extracted from the plasma with dichloromethane after addition of 0.2 mL 1 M NaOH. HPLC separation was performed on a C18 analytical column (250 mm × 4 mm i.d.) with acetonitrile–water, 45:55 (v/v), as mo...
متن کاملMethod Validation and Quantitative Determination of Famotidine in Human Plasma
A simple, selective and accurate reversed-phase high pressure liquid chromatogaphic method with UV detection at 274 nm has been developed for the determination of famotidine in human plasma. The procedure employed ranitidine as an internal standard (IS). A good chromatographic separation between famotidine, internal standard and interfering endogenous peaks was achieved using a a C18 column and...
متن کاملHigh-Performance Liquid Chromatographic Determination of Rivastig-mine in Human Plasma for Application in Pharmacokinetic Studies
A simple and reproducible HPLC method with spectrophotometric detection was developed for determination of rivastigmine in human plasma. Liquid-liquid extraction of rivastigmine and donepezil (as internal standard) from plasma samples was performed with 1-butanol/n-hexane (2:98 v/v) in alkaline condition followed by back-extraction into diluted acetic acid. Chromatography was carried out using ...
متن کاملHigh-Performance Liquid Chromatographic Determination of Rivastig-mine in Human Plasma for Application in Pharmacokinetic Studies
A simple and reproducible HPLC method with spectrophotometric detection was developed for determination of rivastigmine in human plasma. Liquid-liquid extraction of rivastigmine and donepezil (as internal standard) from plasma samples was performed with 1-butanol/n-hexane (2:98 v/v) in alkaline condition followed by back-extraction into diluted acetic acid. Chromatography was carried out using ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 1979
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.59.3.588